What is Ativan?
Ativan (lorazepam) is an intermediate-acting benzodiazepine for anxiety disorders. It has predictable absorption and no active metabolites, making it preferred for certain populations including elderly patients and those with liver issues.
Uses
- Anxiety disorders and anxiety with depression
- Insomnia due to anxiety
- Pre-operative sedation
- Status epilepticus (IV form)
Dosage
Anxiety: 2-6mg/day in divided doses. Insomnia: 2-4mg at bedtime. Elderly: Start 1-2mg/day.
Side Effects
Common: Sedation, dizziness, weakness, unsteadiness
Serious: Respiratory depression, paradoxical agitation, dependence, withdrawal seizures
Precautions
- Black Box Warning: Risk with opioid use
- No active metabolites — safer for liver patients
- Gradual tapering required for discontinuation
- Use lowest effective dose for shortest duration
How does Ativan compare to other benzodiazepines?
Intermediate onset (15-30 min) and duration (6-8 hours). No active metabolites, safer for elderly/liver patients. More potent per mg than Valium.